Kenneth R. Garren's presentation "Presume Guilt; Prove Innocence" discusses the evolution of safety practices in the U.S. space program, emphasizing fatal accidents like Apollo 1, Challenger, and Columbia. Garren reflects on his experiences at NASA Langley and advocates for a fundamental shift in NASA's approach to safety. The talk is organized into sections covering historical missions, major accidents, their causes, and recommendations for future safety protocols.